Ontology highlight
ABSTRACT:
SUBMITTER: Miyashita M
PROVIDER: S-EPMC3165724 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Miyashita Moeko M Oshiumi Hiroyuki H Matsumoto Misako M Seya Tsukasa T
Molecular and cellular biology 20110726 18
The cytoplasmic viral RNA sensors RIG-I and MDA5 are important for the production of type I interferon and other inflammatory cytokines. DDX60 is an uncharacterized DEXD/H box RNA helicase similar to Saccharomyces cerevisiae Ski2, a cofactor of RNA exosome, which is a protein complex required for the integrity of cytoplasmic RNA. Expression of DDX60 increases after viral infection, and the protein localizes at the cytoplasmic region. After viral infection, the DDX60 protein binds to endogenous R ...[more]