Ontology highlight
ABSTRACT:
SUBMITTER: Chiba S
PROVIDER: S-EPMC6144874 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in microbiology 20180912
UAP56, a member of the DExD/H-box RNA helicase family, is essential for pre-mRNA splicing and mRNA export in eukaryotic cells. In influenza A virus-infected cells, UAP56 mediates viral mRNA nuclear export, facilitates viral ribonucleoprotein complex formation through direct interaction with the viral nucleoprotein, and may indirectly affect antiviral host responses by binding to and/or facilitating the activation of the antiviral host factors MxA and PKR. Here, we demonstrate that UAP56 also co- ...[more]