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JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals.

ABSTRACT: We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis.

SUBMITTER: Viscidi RP 

PROVIDER: S-EPMC3166351 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals.

Viscidi Raphael P RP   Khanna Nina N   Tan Chen S CS   Li Xiuhung X   Jacobson Lisa L   Clifford David B DB   Nath Avindra A   Margolick Joseph B JB   Shah Keerti V KV   Hirsch Hans H HH   Koralnik Igor J IJ  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110818 7

We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis. ...[more]

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