Ontology highlight
ABSTRACT:
SUBMITTER: Hu W
PROVIDER: S-EPMC3174342 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Hu Wei W Lu Chunhua C Dong Han Hee HH Huang Jie J Shen De-yu DY Stone Rebecca L RL Nick Alpa M AM Shahzad Mian M K MM Mora Edna E Jennings Nicholas B NB Lee Sun Joo SJ Roh Ju-Won JW Matsuo Koji K Nishimura Masato M Goodman Blake W BW Jaffe Robert B RB Langley Robert R RR Deavers Michael T MT Lopez-Berestein Gabriel G Coleman Robert L RL Sood Anil K AK
Cancer research 20110727 18
Emerging evidence suggests that the Notch/Delta-like ligand 4 (Dll4) pathway may offer important new targets for antiangiogenesis approaches. In this study, we investigated the clinical and biological significance of Dll4 in ovarian cancer. Dll4 was overexpressed in 72% of tumors examined in which it was an independent predictor of poor survival. Patients with tumors responding to anti-VEGF therapy had lower levels of Dll4 than patients with stable or progressive disease. Under hypoxic condition ...[more]