Ontology highlight
ABSTRACT:
SUBMITTER: Patterson M
PROVIDER: S-EPMC3166652 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Patterson Michael M Yasuda Ryohei R
British journal of pharmacology 20110801 8
Synaptic plasticity, or changes in synaptic strength, is thought to underlie learning and memory. Imaging studies, mainly in brain slices, have revealed that long-term synaptic plasticity of excitatory synapses in hippocampal neurons is coupled with structural plasticity of dendritic spines, which is thought to be essential for inducing and regulating functional plasticity. Using pharmacological and genetic manipulation, the signalling network underlying structural plasticity has been extensivel ...[more]