Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka J
PROVIDER: S-EPMC4218863 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Tanaka Jun-Ichi J Horiike Yoshihiro Y Matsuzaki Masanori M Miyazaki Takashi T Ellis-Davies Graham C R GC Kasai Haruo H
Science (New York, N.Y.) 20080228 5870
Long-term potentiation (LTP) at glutamatergic synapses is considered to underlie learning and memory and is associated with the enlargement of dendritic spines. Because the consolidation of memory and LTP require protein synthesis, it is important to clarify how protein synthesis affects spine enlargement. In rat brain slices, the repetitive pairing of postsynaptic spikes and two-photon uncaging of glutamate at single spines (a spike-timing protocol) produced both immediate and gradual phases of ...[more]