Ontology highlight
ABSTRACT:
SUBMITTER: Kashatus DF
PROVIDER: S-EPMC3167028 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Kashatus David F DF Lim Kian-Huat KH Brady Donita C DC Pershing Nicole L K NL Cox Adrienne D AD Counter Christopher M CM
Nature cell biology 20110807 9
Mitochondria exist as dynamic interconnected networks that are maintained through a balance of fusion and fission. Equal distribution of mitochondria to daughter cells during mitosis requires fission. Mitotic mitochondrial fission depends on both the relocalization of the large GTPase DRP1 to the outer mitochondrial membrane and phosphorylation of Ser 616 on DRP1 by the mitotic kinase cyclin B-CDK1 (ref. 2). We now report that these processes are mediated by the small Ras-like GTPase RALA and it ...[more]