Ontology highlight
ABSTRACT:
SUBMITTER: Abrisch RG
PROVIDER: S-EPMC7147108 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Abrisch Robert G RG Gumbin Samantha C SC Wisniewski Brett Taylor BT Lackner Laura L LL Voeltz Gia K GK
The Journal of cell biology 20200401 4
The steady-state morphology of the mitochondrial network is maintained by a balance of constitutive fission and fusion reactions. Disruption of this steady-state morphology results in either a fragmented or elongated network, both of which are associated with altered metabolic states and disease. How the processes of fission and fusion are balanced by the cell is unclear. Here we show that mitochondrial fission and fusion are spatially coordinated at ER membrane contact sites (MCSs). Multiple me ...[more]