Ontology highlight
ABSTRACT:
SUBMITTER: Milstein AD
PROVIDER: S-EPMC3167227 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Neuron 20070901 6
A family of transmembrane AMPA receptor regulatory proteins (TARPs) profoundly affects the trafficking and gating of AMPA receptors (AMPARs). Although TARP subtypes are differentially expressed throughout the CNS, it is unclear whether this imparts functional diversity to AMPARs in distinct neuronal populations. Here, we examine the effects of each TARP subtype on the kinetics of AMPAR gating in heterologous cells and in neurons. We report a striking heterogeneity in the effects of TARP subtypes ...[more]