Ontology highlight
ABSTRACT:
SUBMITTER: Menuz K
PROVIDER: S-EPMC3159041 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Menuz Karen K O'Brien Jessica L JL Karmizadegan Siavash S Bredt David S DS Nicoll Roger A RA
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080801 35
Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary subunits that influence diverse aspects of receptor function. However, the full complement of physiological roles for TARPs in vivo remains poorly understood. Here we find that double knock-out mice lacking TARPs gamma-2 and gamma-3 are profoundly ataxic and fail to thrive. We demonstrate that these TARPs are critical for the synaptic targeting and kinetics of AMPA receptors in cerebellar Golgi cells, but that ei ...[more]