A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception.
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ABSTRACT:
SUBMITTER: Cavallari N
PROVIDER: S-EPMC3167789 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception.
Cavallari Nicola N Frigato Elena E Vallone Daniela D Fröhlich Nadine N Lopez-Olmeda Jose Fernando JF Foà Augusto A Berti Roberto R Sánchez-Vázquez Francisco Javier FJ Bertolucci Cristiano C Foulkes Nicholas S NS
PLoS biology 20110906 9
The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retai ...[more]
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