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Association of alpha B-crystallin genotypes with oral cancer susceptibility, survival, and recurrence in Taiwan.


ABSTRACT: BACKGROUND: Alpha B-crystallin (CRYAB) is a protein that functions as "molecular chaperone" in preserving intracellular architecture and cell membrane. Also, CRYAB is highly antiapoptotic. Abnormal CRYAB expression is a prognostic biomarker for oral cancer, while its genomic variations and the association with carcinogenesis have never been studied. METHODOLOGY/FINDING: Therefore, we hypothesized that CRYAB single nucleotide polymorphisms may be associated with oral cancer risk. In this hospital-based study, the association of CRYAB A-1215G (rs2228387), C-802G (rs14133) and intron2 (rs2070894) polymorphisms with oral cancer in a Taiwan population was investigated. In total, 496 oral cancer patients and 992 age- and gender-matched healthy controls were genotyped and analyzed. A significantly different frequency distribution was found in CRYAB C-802G genotypes, but not in A-1215G and intron2 genotypes, between the oral cancer and control groups. The CRYAB C-802G G allele conferred an increased risk of oral cancer (P?=?1.49×10(-5)). Patients carrying CG/GG at CRYAB C-802G were of lower 5-year survival and higher recurrence rate than those of CC (P<0.05). CONCLUSION/SIGNIFICANCE: Our results provide the first evidence that the G allele of CRYAB C-802G is correlated with oral cancer risk and this polymorphism may be a useful marker for oral cancer recurrence and survival prediction for clinical reference.

SUBMITTER: Bau DT 

PROVIDER: S-EPMC3168435 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Association of alpha B-crystallin genotypes with oral cancer susceptibility, survival, and recurrence in Taiwan.

Bau Da-Tian DT   Tsai Chia-Wen CW   Lin Cheng-Chieh CC   Tsai Ru-Yin RY   Tsai Ming-Hsui MH  

PloS one 20110907 9


<h4>Background</h4>Alpha B-crystallin (CRYAB) is a protein that functions as "molecular chaperone" in preserving intracellular architecture and cell membrane. Also, CRYAB is highly antiapoptotic. Abnormal CRYAB expression is a prognostic biomarker for oral cancer, while its genomic variations and the association with carcinogenesis have never been studied.<h4>Methodology/finding</h4>Therefore, we hypothesized that CRYAB single nucleotide polymorphisms may be associated with oral cancer risk. In  ...[more]

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