Ontology highlight
ABSTRACT:
SUBMITTER: Raymond A
PROVIDER: S-EPMC3169391 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Raymond Amy A Haffner Taryn T Ng Nathan N Lorimer Don D Staker Bart B Stewart Lance L
Acta crystallographica. Section F, Structural biology and crystallization communications 20110813 Pt 9
Any structural genomics endeavor, particularly ambitious ones such as the NIAID-funded Seattle Structural Genomics Center for Infectious Disease (SSGCID) and Center for Structural Genomics of Infectious Disease (CSGID), face technical challenges at all points of the production pipeline. One salvage strategy employed by SSGCID is combined gene engineering and structure-guided construct design to overcome challenges at the levels of protein expression and protein crystallization. Multiple construc ...[more]