Dataset Information

The Scottish Structural Proteomics Facility: targets, methods and outputs.

ABSTRACT: The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.

SUBMITTER: Oke M

PROVIDER: S-EPMC2883930 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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The Scottish Structural Proteomics Facility: targets, methods and outputs.

Oke Muse M Carter Lester G LG Johnson Kenneth A KA Liu Huanting H McMahon Stephen A SA Yan Xuan X Kerou Melina M Weikart Nadine D ND Kadi Nadia N Sheikh Md Arif MA Schmelz Stefan S Dorward Mark M Zawadzki Michal M Cozens Christopher C Falconer Helen H Powers Helen H Overton Ian M IM van Niekerk C A Johannes CA Peng Xu X Patel Prakash P Garrett Roger A RA Prangishvili David D Botting Catherine H CH Coote Peter J PJ Dryden David T F DT Barton Geoffrey J GJ Schwarz-Linek Ulrich U Challis Gregory L GL Taylor Garry L GL White Malcolm F MF Naismith James H JH

Journal of structural and functional genomics 20100424 2

The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm o ...[more]

PMID: 20419351

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Dataset Information

The Scottish Structural Proteomics Facility: targets, methods and outputs.

Publications

The Scottish Structural Proteomics Facility: targets, methods and outputs.

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