Ontology highlight
ABSTRACT:
SUBMITTER: Begley DW
PROVIDER: S-EPMC3169404 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Begley Darren W DW Edwards Thomas E TE Raymond Amy C AC Smith Eric R ER Hartley Robert C RC Abendroth Jan J Sankaran Banumathi B Lorimer Donald D DD Myler Peter J PJ Staker Bart L BL Stewart Lance J LJ
Acta crystallographica. Section F, Structural biology and crystallization communications 20110816 Pt 9
Babesiosis is a tick-borne disease caused by eukaryotic Babesia parasites which are morphologically similar to Plasmodium falciparum, the causative agent of malaria in humans. Like Plasmodium, different species of Babesia are tuned to infect different mammalian hosts, including rats, dogs, horses and cattle. Most species of Plasmodium and Babesia possess an essential bifunctional enzyme for nucleotide synthesis and folate metabolism: dihydrofolate reductase-thymidylate synthase. Although thymidy ...[more]