Ontology highlight
ABSTRACT:
SUBMITTER: Tebas P
PROVIDER: S-EPMC3169584 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Tebas Pablo P Tuluc Florin F Barrett Jeffrey S JS Wagner Wayne W Kim Deborah D Zhao Huaquing H Gonin René R Korelitz James J Douglas Steven D SD
PloS one 20110908 9
<h4>Background</h4>Neurokinin-1 receptor (NK1R) antagonists have anti-HIV activity in monocyte-derived macrophages, decrease CCR5 expression and improve natural killer cell function ex vivo. Aprepitant is a NK1R antagonist approved by FDA as an antiemetic.<h4>Methods</h4>We conducted a phase IB randomized, placebo controlled, double masked study to evaluate the safety, antiviral activity, pharmacokinetics and immune-modulatory effects of aprepitant in HIV-infected adults not receiving antiretrov ...[more]