Ontology highlight
ABSTRACT:
SUBMITTER: Halik PK
PROVIDER: S-EPMC7466001 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Halik Paweł K PK Lipiński Piotr F J PFJ Matalińska Joanna J Koźmiński Przemysław P Misicka Aleksandra A Gniazdowska Ewa E
Molecules (Basel, Switzerland) 20200818 16
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action. In the presented research, we developed two novel structural modifications of aprepitant to create aprepitant conjugates with different radionuclide chelators. All of them were radiolabeled with <sup>68</sup>Ga and <sup>177</sup>Lu radionuclides and evaluated in terms of their ...[more]