Ontology highlight
ABSTRACT:
SUBMITTER: Lamkanfi M
PROVIDER: S-EPMC3170132 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Lamkanfi Mohamed M Vande Walle Lieselotte L Kanneganti Thirumala-Devi TD
Immunological reviews 20110901 1
Inflammasomes are multi-protein complexes that sense microbial molecules and endogenous danger signals in intracellular compartments. Inflammasome assembly results in caspase-1 activation, which in turn drives maturation and secretion of the pro-inflammatory cytokines interleukin 1β (IL-1β) and IL-18, and induces pyroptosis to eliminate the infectious agent. The importance of inflammasomes in regulating immune responses was recognized with the discovery of polymorphisms in genes encoding inflamm ...[more]