Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.
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ABSTRACT:
SUBMITTER: Schieber AM
PROVIDER: S-EPMC4732872 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.
Schieber Alexandria M Palaferri AM Lee Yujung Michelle YM Chang Max W MW Leblanc Mathias M Collins Brett B Downes Michael M Evans Ronald M RM Ayres Janelle S JS
Science (New York, N.Y.) 20151001 6260
Infections and inflammation can lead to cachexia and wasting of skeletal muscle and fat tissue by as yet poorly understood mechanisms. We observed that gut colonization of mice by a strain of Escherichia coli prevents wasting triggered by infections or physical damage to the intestine. During intestinal infection with the pathogen Salmonella Typhimurium or pneumonic infection with Burkholderia thailandensis, the presence of this E. coli did not alter changes in host metabolism, caloric uptake, o ...[more]
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