Ontology highlight
ABSTRACT:
SUBMITTER: Maffeo C
PROVIDER: S-EPMC3170404 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Maffeo Christopher C Schöpflin Robert R Brutzer Hergen H Stehr René R Aksimentiev Aleksei A Wedemann Gero G Seidel Ralf R
Physical review letters 20101004 15
DNA-DNA interactions are important for genome compaction and transcription regulation. In studies of such complex processes, DNA is often modeled as a homogeneously charged cylinder and its electrostatic interactions are calculated within the framework of the Poisson-Boltzmann equation. Commonly, a charge adaptation factor is used to address limitations of this theoretical approach. Despite considerable theoretical and experimental efforts, a rigorous quantitative assessment of this parameter is ...[more]