Ontology highlight
ABSTRACT:
SUBMITTER: Kim SH
PROVIDER: S-EPMC6301789 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
eLife 20181207
The three-dimensional organization of DNA is increasingly understood to play a decisive role in vital cellular processes. Many studies focus on the role of DNA-packaging proteins, crowding, and confinement in arranging chromatin, but structural information might also be directly encoded in bare DNA itself. Here, we visualize plectonemes (extended intertwined DNA structures formed upon supercoiling) on individual DNA molecules. Remarkably, our experiments show that the DNA sequence directly encod ...[more]