Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC3171173 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Yuan Yunyun Y Elbegdorj Orgil O Chen Jianyang J Akubathini Shashidhar K SK Beletskaya Irina O IO Selley Dana E DE Zhang Yan Y
Bioorganic & medicinal chemistry letters 20110718 18
Mu opioid receptor antagonists have been applied to target a variety of diseases clinically. The current study is designed to explore the structure selectivity relationship (SSR) of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan (NAP), a lead compound identified as a selective mu opioid receptor antagonist based on the previous study. Among a series of NAP derivatives synthesized, compounds 6 (NMP) and 9 (NGP) maintained comparable binding affinity, selecti ...[more]