Ontology highlight
ABSTRACT:
SUBMITTER: Francalanci P
PROVIDER: S-EPMC7460809 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Francalanci Paola P Giovannoni Isabella I De Stefanis Cristiano C Romito Ilaria I Grimaldi Chiara C Castellano Aurora A D'Oria Valentina V Alaggio Rita R Alisi Anna A
International journal of molecular sciences 20200812 16
Focal adhesion kinase (FAK) is over-expressed and is correlated with aggressiveness in adult hepatocellular carcinoma (HCC). Inhibition of FAK decreases HCC invasiveness by down-regulating Enhancer of Zeste homolog 2 (EZH2), an epigenetic controller, that acts in transcriptional repression of a large number of genes via histone 3 methylation of lysine 27 (H3K27me3). Here, we investigated the hepatic expression of total FAK, EZH2, H3K27me3, and proliferating cell nuclear antigen (PCNA) in 17 pedi ...[more]