Ontology highlight
ABSTRACT:
SUBMITTER: Malladi VL
PROVIDER: S-EPMC3171587 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Malladi Venkata L A VL Sobczak Adam J AJ Maricic Natalie N Murugapiran Senthil Kumar SK Schneper Lisa L Makemson John J Mathee Kalai K Wnuk Stanislaw F SF
Bioorganic & medicinal chemistry 20110728 18
Quorum sensing (QS) is a population-dependent signaling process bacteria use to control multiple processes including virulence that is critical for establishing infection. The most common QS signaling molecule used by Gram-negative bacteria are acylhomoserine lactones. The development of non-native acylhomoserine lactone (AHL) ligands has emerged as a promising new strategy to inhibit QS in Gram-negative bacteria. In this work, we have synthesized a set of optically pure γ-lactams and their redu ...[more]