Ontology highlight
ABSTRACT:
SUBMITTER: Kim M
PROVIDER: S-EPMC3171630 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Kim Minkyung M Roesener Andrew P AP Mendonca Philipe R F PR Mastick Grant S GS
Developmental biology 20110723 1
Pioneer longitudinal axons grow long distances parallel to the floor plate and precisely maintain their positions using guidance molecules released from the floor plate. Two receptors, Robo1 and Robo2, are critical for longitudinal axon guidance by the Slit family of chemorepellents. Previous studies showed that Robo1(-/-);2(-/-) double mutant mouse embryos have disruptions in both ventral and dorsal longitudinal tracts. However, the role of each Robo isoform remained unclear, because Robo1 or 2 ...[more]