Ontology highlight
ABSTRACT:
SUBMITTER: Blockus H
PROVIDER: S-EPMC8605498 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Blockus Heike H Rolotti Sebi V SV Szoboszlay Miklos M Peze-Heidsieck Eugénie E Ming Tiffany T Schroeder Anna A Apostolo Nuno N Vennekens Kristel M KM Katsamba Phinikoula S PS Bahna Fabiana F Mannepalli Seetha S Ahlsen Goran G Honig Barry B Shapiro Lawrence L de Wit Joris J Losonczy Attila A Polleux Franck F
Cell reports 20211001 3
Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in establishing synaptic specificity in hippocampal CA1. In vivo, Robo2 is present and required postsynaptically in CA1 pyramidal neurons (PNs) for the formation of excitatory (E) but not inhibitory (I) synapses, specifically in proximal but not distal dendritic compartments. In vitro approaches show that the synaptogenic a ...[more]