Ontology highlight
ABSTRACT:
SUBMITTER: Hagen N
PROVIDER: S-EPMC3172106 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Hagen N N Hans M M Hartmann D D Swandulla D D van Echten-Deckert G G
Cell death and differentiation 20110218 8
We have recently reported that the bioactive lipid sphingosine-1-phosphate (S1P), usually signaling proliferation and anti-apoptosis induces neuronal death when generated by sphingosine-kinase2 and when accumulation due to S1P-lyase deficiency occurs. In the present study, we identify the signaling cascade involved in the neurotoxic effect of sphingoid-base phosphates. We demonstrate that the calcium-dependent cysteine protease calpain mediates neurotoxicity by induction of the endoplasmic retic ...[more]