Ontology highlight
ABSTRACT:
SUBMITTER: Pulkoski-Gross MJ
PROVIDER: S-EPMC5476942 | biostudies-literature | 2015 Jul-Aug
REPOSITORIES: biostudies-literature
Critical reviews in biochemistry and molecular biology 20150429 4
Sphingolipids represent an important class of bioactive signaling lipids which have key roles in numerous cellular processes. Over the last few decades, the levels of bioactive sphingolipids and/or their metabolizing enzymes have been realized to be important factors involved in disease development and progression, most notably in cancer. Targeting sphingolipid-metabolizing enzymes in disease states has been the focus of many studies and has resulted in a number of pharmacological inhibitors, wi ...[more]