Ontology highlight
ABSTRACT:
SUBMITTER: Colon-Franco JM
PROVIDER: S-EPMC3172187 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Colón-Franco Jessica M JM Gomez Timothy S TS Billadeau Daniel D DD
Journal of cell science 20110824 Pt 18
Formin-like 1 (FMNL1) is a member of the formin family of actin nucleators, and is one of the few formins for which in vitro activities have been well characterized. However, the functional roles of this mammalian formin remain ill-defined. In particular, it is unclear how the unique in vitro biochemical properties of FMNL1 relate to its regulation of cellular processes. Here, we demonstrate that FMNL1 depletion caused a dramatic increase in cellular F-actin content, which resulted in Golgi comp ...[more]