CREB is activated by muscle injury and promotes muscle regeneration.
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ABSTRACT:
SUBMITTER: Stewart R
PROVIDER: S-EPMC3172299 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
CREB is activated by muscle injury and promotes muscle regeneration.
Stewart Randi R Flechner Lawrence L Montminy Marc M Berdeaux Rebecca R
PloS one 20110913 9
The cAMP response element binding protein (CREB) plays key roles in differentiation of embryonic skeletal muscle progenitors and survival of adult skeletal muscle. However, little is known about the physiologic signals that activate CREB in normal muscle. Here we show that CREB phosphorylation and target genes are induced after acute muscle injury and during regeneration due to genetic mutation. Activated CREB localizes to both myogenic precursor cells and newly regenerating myofibers within reg ...[more]
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