Ontology highlight
ABSTRACT:
SUBMITTER: Edelson BT
PROVIDER: S-EPMC3172670 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Edelson Brian T BT Bradstreet Tara R TR Hildner Kai K Carrero Javier A JA Frederick Katherine E KE KC Wumesh W Belizaire Roger R Aoshi Taiki T Schreiber Robert D RD Miller Mark J MJ Murphy Theresa L TL Unanue Emil R ER Murphy Kenneth M KM
Immunity 20110801 2
CD8α(+) dendritic cells (DCs) prime cytotoxic T lymphocytes during viral infections and produce interleukin-12 in response to pathogens. Although the loss of CD8α(+) DCs in Batf3(-/-) mice increases their susceptibility to several pathogens, we observed that Batf3(-/-) mice exhibited enhanced resistance to the intracellular bacterium Listeria monocytogenes. In wild-type mice, Listeria organisms, initially located in the splenic marginal zone, migrated to the periarteriolar lymphoid sheath (PALS) ...[more]