Ontology highlight
ABSTRACT:
SUBMITTER: Ferraro GB
PROVIDER: S-EPMC3173120 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Ferraro Gino B GB Morrison Charlotte J CJ Overall Christopher M CM Strittmatter Stephen M SM Fournier Alyson E AE
The Journal of biological chemistry 20110718 36
Nogo-66 receptor 1 (NgR1) is a glycosylphosphatidylinositol-anchored receptor for myelin-associated inhibitors that restricts plasticity and axonal regrowth in the CNS. NgR1 is cleaved from the cell surface of SH-SY5Y neuroblastoma cells in a metalloproteinase-dependent manner; however, the mechanism and physiological consequence of NgR1 shedding have not been explored. We now demonstrate that NgR1 is shed from multiple populations of primary neurons. Through a loss-of-function approach, we foun ...[more]