Ontology highlight
ABSTRACT:
SUBMITTER: Specht CG
PROVIDER: S-EPMC3173796 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Specht Christian G CG Grünewald Nora N Pascual Olivier O Rostgaard Nina N Schwarz Günter G Triller Antoine A
The EMBO journal 20110809 18
Glycine receptors (GlyRs) can dynamically exchange between synaptic and extrasynaptic locations through lateral diffusion within the plasma membrane. Their accumulation at inhibitory synapses depends on the interaction of the β-subunit of the GlyR with the synaptic scaffold protein gephyrin. An alteration of receptor-gephyrin binding could thus shift the equilibrium between synaptic and extrasynaptic GlyRs and modulate the strength of inhibitory neurotransmission. Using a combination of dynamic ...[more]