Ontology highlight
ABSTRACT:
SUBMITTER: Wang CY
PROVIDER: S-EPMC4405633 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Wang Chen-Yu CY Lin Hui-Ching HC Song Yi-Ping YP Hsu Yu-Ting YT Lin Shu-Yu SY Hsu Pei-Chien PC Lin Chun-Hua CH Hung Chia-Chi CC Hsu Min-Ching MC Kuo Yi-Min YM Lee Yih-Jing YJ Hsu Chung Y CY Lee Yi-Hsuan YH
Molecular and cellular biology 20150309 10
Growth-associated protein 43 (GAP43) is known to regulate axon growth, but whether it also plays a role in synaptogenesis remains unclear. Here, we found that GAP43 regulates the aggregation of gephyrin, a pivotal protein for clustering postsynaptic GABA(A) receptors (GABA(A)Rs), in developing cortical neurons. Pharmacological blockade of either protein kinase C (PKC) or neuronal activity increased both GAP43-gephyrin association and gephyrin misfolding-induced aggregation, suggesting the import ...[more]