Ontology highlight
ABSTRACT:
SUBMITTER: McSorley HJ
PROVIDER: S-EPMC3174943 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
McSorley Henry J HJ Gaze Soraya S Daveson James J Jones Dianne D Anderson Robert P RP Clouston Andrew A Ruyssers Nathalie E NE Speare Richard R McCarthy James S JS Engwerda Christian R CR Croese John J Loukas Alex A
PloS one 20110916 9
We present immunological data from two clinical trials where the effect of experimental human hookworm (Necator americanus) infection on the pathology of celiac disease was evaluated. We found that basal production of Interferon- (IFN-)γ and Interleukin- (IL-)17A from duodenal biopsy culture was suppressed in hookworm-infected participants compared to uninfected controls. Increased levels of CD4+CD25+Foxp3+ cells in the circulation and mucosa are associated with active celiac disease. We show th ...[more]