Ontology highlight
ABSTRACT:
SUBMITTER: Bouziat R
PROVIDER: S-EPMC5506690 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bouziat Romain R Hinterleitner Reinhard R Brown Judy J JJ Stencel-Baerenwald Jennifer E JE Ikizler Mine M Mayassi Toufic T Meisel Marlies M Kim Sangman M SM Discepolo Valentina V Pruijssers Andrea J AJ Ernest Jordan D JD Iskarpatyoti Jason A JA Costes Léa M M LM Lawrence Ian I Palanski Brad A BA Varma Mukund M Zurenski Matthew A MA Khomandiak Solomiia S McAllister Nicole N McAllister Nicole N Aravamudhan Pavithra P Boehme Karl W KW Hu Fengling F Samsom Janneke N JN Reinecker Hans-Christian HC Kupfer Sonia S SS Guandalini Stefano S Semrad Carol E CE Abadie Valérie V Khosla Chaitan C Barreiro Luis B LB Xavier Ramnik J RJ Ng Aylwin A Dermody Terence S TS Jabri Bana B
Science (New York, N.Y.) 20170401 6333
Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (T<sub>H</sub>1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elic ...[more]