Ontology highlight
ABSTRACT:
SUBMITTER: Cesselli D
PROVIDER: S-EPMC3175070 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Cesselli Daniela D Beltrami Antonio P AP D'Aurizio Federica F Marcon Patrizia P Bergamin Natascha N Toffoletto Barbara B Pandolfi Maura M Puppato Elisa E Marino Laura L Signore Sergio S Livi Ugolino U Verardo Roberto R Piazza Silvano S Marchionni Luigi L Fiorini Claudia C Schneider Claudio C Hosoda Toru T Rota Marcello M Kajstura Jan J Anversa Piero P Beltrami Carlo A CA Leri Annarosa A
The American journal of pathology 20110519 1
Currently, it is unknown whether defects in stem cell growth and differentiation contribute to myocardial aging and chronic heart failure (CHF), and whether a compartment of functional human cardiac stem cells (hCSCs) persists in the decompensated heart. To determine whether aging and CHF are critical determinants of the loss in growth reserve of the heart, the properties of hCSCs were evaluated in 18 control and 23 explanted hearts. Age and CHF showed a progressive decrease in functionally comp ...[more]