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Architecture, constraints, and behavior.


ABSTRACT: This paper aims to bridge progress in neuroscience involving sophisticated quantitative analysis of behavior, including the use of robust control, with other relevant conceptual and theoretical frameworks from systems engineering, systems biology, and mathematics. Familiar and accessible case studies are used to illustrate concepts of robustness, organization, and architecture (modularity and protocols) that are central to understanding complex networks. These essential organizational features are hidden during normal function of a system but are fundamental for understanding the nature, design, and function of complex biologic and technologic systems.

SUBMITTER: Doyle JC 

PROVIDER: S-EPMC3176601 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Architecture, constraints, and behavior.

Doyle John C JC   Csete Marie M  

Proceedings of the National Academy of Sciences of the United States of America 20110725


This paper aims to bridge progress in neuroscience involving sophisticated quantitative analysis of behavior, including the use of robust control, with other relevant conceptual and theoretical frameworks from systems engineering, systems biology, and mathematics. Familiar and accessible case studies are used to illustrate concepts of robustness, organization, and architecture (modularity and protocols) that are central to understanding complex networks. These essential organizational features a  ...[more]

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