Ontology highlight
ABSTRACT:
SUBMITTER: Jin P
PROVIDER: S-EPMC3179271 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Jin Peng P Duan Rui R Luo Fengbao F Zhang Guofeng G Hong Sabrina N SN Chen Elizabeth H EH
Developmental cell 20110501 5
Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled by Blown fuse (Blow), a cytoplasmic protein required for myoblast fusion but whose molecular function has been elusive. We demonstrate that Blow is an FCM-specific protein that col ...[more]