Ontology highlight
ABSTRACT:
SUBMITTER: Sand PG
PROVIDER: S-EPMC3180252 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Sand Philipp G PG Langguth Berthold B Kleinjung Tobias T
Behavioral and brain functions : BBF 20110907
Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an underlying disturbance of sensory excitability due to changes in ion conductance. The present study addresses the potassium channel subunit gene KCNE3 as a potential candidate for tinnitus susceptibility. 288 Caucasian outpatients with a diagnosis of chronic tinnitus were systematically screened for mutations in the KCNE3 open reading frame and in the adjacent region by direct sequencing. Allele f ...[more]