Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt FI
PROVIDER: S-EPMC3181475 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Schmidt Florian Ingo FI Bleck Christopher Karl Ernst CK Helenius Ari A Mercer Jason J
The EMBO journal 20110726 17
Vaccinia virus (VACV), the model poxvirus, produces two types of infectious particles: mature virions (MVs) and extracellular virions (EVs). EV particles possess two membranes and therefore require an unusual cellular entry mechanism. By a combination of fluorescence and electron microscopy as well as flow cytometry, we investigated the cellular processes that EVs required to infect HeLa cells. We found that EV particles were endocytosed, and that internalization and infection depended on actin ...[more]