Ontology highlight
ABSTRACT:
SUBMITTER: Villa NY
PROVIDER: S-EPMC2862966 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Villa Nancy Y NY Bartee Eric E Mohamed Mohamed R MR Rahman Masmudur M MM Barrett John W JW McFadden Grant G
Virology 20100324 2
Myxoma (MYXV) and vaccinia (VACV) viruses have recently emerged as potential oncolytic agents that can infect and kill different human cancer cells. Although both are structurally similar, it is unknown whether the pathway(s) used by these poxviruses to enter and cause oncolysis in cancer cells are mechanistically similar. Here, we compared the entry of MYXV and VACV-WR into various human cancer cells and observed significant differences: 1--low-pH treatment accelerates fusion-mediated entry of ...[more]