Ontology highlight
ABSTRACT:
SUBMITTER: Zhu R
PROVIDER: S-EPMC3182303 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Zhu Rui R Kiser Jennifer J JJ Seifart Heiner I HI Werely Cedric J CJ Mitchell Charles D CD D'Argenio David Z DZ Fletcher Courtney V CV
Journal of clinical pharmacology 20110510 4
The roles of the NAT2 genotype and enzyme maturation on isoniazid pharmacokinetics were investigated in South African infants with perinatal HIV exposure enrolled in a randomized, double-blind, controlled trial of isoniazid for prevention of tuberculosis disease and latent infection. Plasma concentration-time measurements of isoniazid from 151 infants (starting at 3-4 months of age) receiving isoniazid 10 to 20 mg/kg/d orally during the course of the 24-month study were incorporated in a populat ...[more]