Ontology highlight
ABSTRACT:
SUBMITTER: Wong CC
PROVIDER: S-EPMC3182724 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Wong Carmen Chak-Lui CC Gilkes Daniele M DM Zhang Huafeng H Chen Jasper J Wei Hong H Chaturvedi Pallavi P Fraley Stephanie I SI Wong Chun-Ming CM Khoo Ui-Soon US Ng Irene Oi-Lin IO Wirtz Denis D Semenza Gregg L GL
Proceedings of the National Academy of Sciences of the United States of America 20110912 39
Primary tumors facilitate metastasis by directing bone marrow-derived cells (BMDCs) to colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, and LOX-like 4, which catalyze collagen cross-linking in the lungs before BMDC recruitment. Only a subset of LOX family members w ...[more]