Ontology highlight
ABSTRACT:
SUBMITTER: Imai T
PROVIDER: S-EPMC3182735 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Imai Takashi T Kato Yu Y Kajiwara Chiaki C Mizukami Shusaku S Ishige Ikuo I Ichiyanagi Tomoko T Hikida Masaki M Wang Ji-Yang JY Udono Heiichiro H
Proceedings of the National Academy of Sciences of the United States of America 20110919 39
In antigen (Ag) cross-presentation, dendritic cells (DCs) take up extracellular Ag and translocate them from the endosome to the cytosol for proteasomal degradation. The processed peptides can enter the conventional MHC I pathway. The molecules responsible for the translocation of Ag across the endosomal membrane into the cytosol are unknown. Here we demonstrate that heat shock protein 90 (HSP90) is critical for this step. Cross-presentation and -priming were decreased in both HSP90α-null DCs an ...[more]