Ontology highlight
ABSTRACT:
SUBMITTER: Lee KH
PROVIDER: S-EPMC3183071 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Lee Kuo Hao KH Miller Craig R CR Nagel Anna C AC Wichman Holly A HA Joyce Paul P Ytreberg F Marty FM
PloS one 20110929 9
The relationship between mutation, protein stability and protein function plays a central role in molecular evolution. Mutations tend to be destabilizing, including those that would confer novel functions such as host-switching or antibiotic resistance. Elevated temperature may play an important role in preadapting a protein for such novel functions by selecting for stabilizing mutations. In this study, we test the stability change conferred by single mutations that arise in a G4-like bacterioph ...[more]