Ontology highlight
ABSTRACT:
SUBMITTER: Furini S
PROVIDER: S-EPMC3183810 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Furini Simone S Domene Carmen C
Biophysical journal 20111001 7
The NaK channel is a cation selective channel with similar permeability for K(+) and Na(+). The available crystallographic structure of wild-type (WT) NaK is usually associated with a conductive state of the channel. Here, potential of mean force for complete conduction events of Na(+) and K(+) ions through NaK show that: i), large energy barriers prevent the passage of ions through the WT NaK structure, ii), the barriers are correlated to the presence of a hydrogen bond between Asp-66 and Asn-6 ...[more]