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Design and synthesis of a novel triptycene-based ligand for modeling carboxylate-bridged diiron enzyme active sites.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3184322 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Design and synthesis of a novel triptycene-based ligand for modeling carboxylate-bridged diiron enzyme active sites.
Organic letters 20110829 19
A novel triptycene-based ligand with a preorganized framework was designed to model carboxylate-bridged diiron active sites in bacterial multicomponent monooxygenase (BMM) hydroxylase enzymes. The synthesis of the bis(benzoxazole)-appended ligand L1 depicted was accomplished in 11 steps. Reaction of L1 with iron(II) triflate and a carboxylate source afforded the desired diiron(II) complex [Fe(2)L1(μ-OH)(μ-O(2)CAr(Tol))(OTf)(2)]. ...[more]