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Heterogeneous catalytic hydrogenation of unprotected indoles in water: a green solution to a long-standing challenge.

ABSTRACT: An environmentally benign procedure for the hydrogenation of unprotected indoles is described. The hydrogenation reaction is catalyzed by Pt/C and activated by p-toluenesulfonic acid in water as a solvent. The efficacy of the method is illustrated by the hydrogenation of a variety of substituted indoles to their corresponding indolines which were obtained in excellent yields.

SUBMITTER: Kulkarni A

PROVIDER: S-EPMC3184324 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Heterogeneous catalytic hydrogenation of unprotected indoles in water: a green solution to a long-standing challenge.

Kulkarni Aditya A Zhou Weihong W Török Béla B

Organic letters 20110908 19

An environmentally benign procedure for the hydrogenation of unprotected indoles is described. The hydrogenation reaction is catalyzed by Pt/C and activated by p-toluenesulfonic acid in water as a solvent. The efficacy of the method is illustrated by the hydrogenation of a variety of substituted indoles to their corresponding indolines which were obtained in excellent yields. ...[more]

PMID: 21902212

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