Ontology highlight
ABSTRACT:
SUBMITTER: Block ER
PROVIDER: S-EPMC3184351 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Block Ethan R ER Tolino Michael A MA Klarlund Jes K JK
Cellular signalling 20110804 12
Wounding usually causes considerable cell damage, and released ATP promotes migration of nearby epithelium. ATP binds to purinergic receptors on the cell surface and induces transactivation of the EGF receptor through signaling by the Src family kinases (SFKs). Here we tested whether ATP activates these kinases through Pyk2, a member of the focal adhesion kinase family. Pyk2 was rapidly and potently activated by treating corneal epithelial cells with ATP, and physical interaction of Pyk2 with th ...[more]